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Nutrients for Women’s Health

The women’s health sector continues to be a key space for dietary complement ingredient producers. Deepening analysis is connecting complement advantages to a variety of women’s health circumstances, spanning younger maturity to post-menopause.



For youthful women, many dietary supplements are marketed to help pores and skin and hair, in addition to fertility and fetal improvement. For older women, the main target shifts to cardiovascular, joint, mind and bone health help, stated Matthew Roberts, Ph.D., chief scientific officer, KGK Science. “There has also been a trend to market multivitamins that are formulated with a micronutrient profile that benefit physical aspects such as bone density, hormonal levels, and longevity.”

Healthier way of life modifications and an elevated curiosity in handy, holistically improved health are on the core of the women’s wellness motion, and so is the demand for merchandise with research-supported outcomes. “Women’s needs have not been properly addressed in terms of research and development (R&D) that is conducted on products,” commented Megan Luu, advertising coordinator, GE Nutrients Inc. She added merchandise examined totally on males which might be rebranded and marketed to women might not solely be physiologically ineffective, they could additionally trigger hostile results. “Women are looking for products that work optimally for them, so supplements that have actually been developed and tested specifically for women, and are verified as such, are in increasing demand.”

Skin health and longevity is a main focus for Lycored, a part of Adama Group. The firm’s proprietary ingestible lycopene-based skincare know-how, Lycored Nutrient Complex (LNC) for Skin™, was researched in a managed medical trial and located to be each protected and efficient in defending the pores and skin from UV injury, selling elasticity and contributing to the pores and skin’s longevity. The ingredient’s most lately revealed pores and skin health and wonder research was revealed within the fourth quarter of 2016.1

Cranberry juice’s position in preventing off urinary tract infections (UTI) got here underneath scrutiny final yr,2 nevertheless many women proceed to show to it for urinary tract health. Cran-Max®, a concentrated cranberry ingredient from Proprietary Nutritionals Inc., is made with a proprietary course of that makes use of cranberry pores and skin, seeds, pulp, juice and fiber with none of the solvents, preservatives, sugars, water, flavorings or shade related to cranberry juice.

“Unlike antibiotics, which kill bacteria, cranberry works by changing the bacterial structure and preventing adhesion to tissues so it works effectively for prevention without the risk of developing antibiotic resistance,” stated Dean Mosca, president, Proprietary Nutritionals Inc.

A peer-reviewed research in contrast the consequences of a generally prescribed antibiotic to Cran-Max in women with reoccurring UTIs and located Cran-Max was similar to an antibiotic for UTI prevention.Three The research confirmed taking one, 500mg dose of Cran-Max, began working instantly on UTIs, in distinction to different cranberry dietary supplements that must be taken for longer durations of time earlier than seeing a response.

For lactating and pregnant women who plan to breastfeed, a current research linked the consumption of Benexia chia oil, one of many highest plant sources of omega-Three important fatty acids (EFAs) and alpha linolenic acid (ALA), to transferring excessive ranges of docosahexaenoic acid (DHA) to infants throughout breastfeeding.four DHA is important for the formation and performance of the nervous system and imaginative and prescient.

Half of the 40 wholesome pregnant women (22 to 35 years previous) enrolled within the research acquired 16 mL of chia oil day by day from the third trimester of being pregnant till the first six months of nursing. The moms within the chia group skilled a “significant” improve within the ranges of omega-Three EFAs in breast milk, particularly ALA (60 %) and DHA (50 %). They additionally had will increase within the quantities of ALA (76 %), and eicosapentaenoic acid (EPA) (57 %) of their purple blood cells.

Maintaining a perfect weight is a tenet of excellent health, however hormone fluctuations and menopause can impression any lady’s greatest intentions. ID-alG™ from Nexira is a brown seaweed extract (Ascophyllum nodosum) wealthy in long-chain polyphenols referred to as phlorotannins, which have pure weight administration properties.

Julie Impérato, advertising supervisor, Nexira, stated in vitro checks confirmed these lengthy chain polyphenols blocked the exercise of the 2 fundamental digestive enzymes (lipase and amylase) by greater than 50 %, decreasing the digestion of fat and carbohydrates. She additionally cited an unpublished, 16-week medical research that demonstrated ID-alG’s influence on weight reduction, stomach and visceral fats loss, and physique form enchancment on women aged 45 and over, with a physique mass index (BMI) larger than 25. “At the daily intake of 400 mg/d, ID-alG showed an average weight loss of 3.6 kg, which was significantly higher than the placebo group [with] positive effects observed as early as eight weeks after the beginning of the clinical trial,” she stated. “The study confirmed that ID-alG has a targeted efficacy on body fat mass with an average fat mass loss reaching -2.3 kg.”

Fiber and probiotics also can contribute to weight administration by means of selling intestine health, satiety and optimum digestion. Oliggo-Fiber® from Cargill is a soluble chicory root fiber (inulin) that may be included into meals and drinks with out affecting the style or texture of the ultimate product.

“Chicory root fiber has a prebiotic effect, modulating selectively ‘beneficial’ gut bacteria such as bifidobacteria and improving the conditions in the gut/colon,”5 famous Pam Stauffer, international advertising packages supervisor at Cargill. She added that it’s additionally thought chicory root fiber might help wholesome bones by boosting calcium absorption in sure subgroups of the inhabitants, notably pre-teenage women and post-menopausal women. “This enhanced calcium absorption occurs in the large intestine rather than the stomach or small intestine,” she stated. “As a result of fermentation, short-chain fatty acids are produced, which lowers the pH of the intestine. This environment solubilizes the calcium, making it more available.”

Cardiovascular illness (CVD) continues to rank because the primary reason for mortality for women, claiming one out of each 4 women, based on the American Heart Association (AHA). Proliva® SOFE (Spanish olive fruit extract), from Euromed, helps cardiovascular health in women with 20 % hydroxytyrosol, one of many essential phytonutrients present in additional virgin olive oil and olives.

“The hydroxytyrosol in Proliva SOFE has been shown to be a powerful antioxidant, to maintain the health of blood vessel linings and support normal blood circulation,” stated Guy Woodman, basic supervisor, Euromed.

A current research discovered 500 mg of Proliva improved arterial elasticity and lowered triglycerides.6 Twelve of 36 topics enrolled within the 11-day, double-blind, placebo-controlled research have been assigned to 3 teams, receiving both 250 mg of Proliva, 500 mg of Proliva or a placebo. The group that acquired 500 mg confirmed a imply triglyceride degree lower of 21.64 %, probably the most vital change amongst all three teams.

MenaQ7® vitamin K2 as MK-7 (menaquinone-7) from NattoPharma USA, has been discovered to have a dual-pronged impact on each coronary heart and bone health. Eric Anderson, senior vice chairman of worldwide gross sales and advertising, NattoPharma, stated the ingredient works by activating proteins already current within the physique that assist the physique correctly use calcium. “It activates osteocalcin, which binds calcium to the bone mineral matrix, and matrix Gla protein (MGP), which inhibits calcium from depositing in arteries and blood vessels, supporting cardiovascular health,” he says.

MenaQ7’s cardiovascular benefit was documented in a 2015 research.7 Researchers monitored 244 wholesome post-menopausal women for three years utilizing pulse wave velocity and ultrasound methods. The individuals have been randomly assigned to take 180 mcg of vitamin K2 as MK-7 (MenaQ7) every day or placebo. After the three years, women within the placebo group skilled elevated arterial stiffness whereas these within the MenaQ7 group skilled measurably improved flexibility of their arteries.

Regarding bone health, a three-year research of MenaQ7 on 244 wholesome women confirmed a every day dose of 180 mcg of vitamin K2 as MK-7 delivered safety of the vertebrae and the hip towards bone loss.eight “Women taking MenaQ7® exhibited significantly increased circulating active osteocalcin, which is a well-established biomarker for bone and vitamin K status,” Anderson stated. He added that after three years of supplementation, upkeep in each bone mineral content material and bone mineral density continued. “Bone strength was also statistically improved, demonstrating therapeutic benefits for the MK-7 group versus the placebo group. This was not only statistically significant, but clinically relevant—ongoing MK-7 supplementation would essentially push the risk of fracture beyond life expectancy.”

A lady’s transition to into menopause brings a number of latest health points. The selection to start hormone alternative remedy (HRT) to fight scorching flashes, night time sweats, vaginal dryness, sleeplessness, temper swings, joint discomfort related to menopause is one which’s weighed closely.  “Women are very cautious when buying products,” stated Michael Jeffers, president and CEO, Helios Corp.

“This is directly attributed to the 15,000-women HRT study conducted in 2002, where a significant percentage of women in the active group were tested and confirmed with multiple forms of cancer, combined with the negative reports of Black Cohosh links to liver toxicity and soy isoflavone links to estrogenicity.”9

Helios Corp. is the unique vendor of EstroG-100®, a “hormone balancing” mix of hot-water-extracted Phlomis umbrosa, Cynanchum wilfordii and Angelica gigas Nakai (Korean Angelica) herbs, “all of which have at least 400 years of documented usage in Korea and China,” in response to the corporate. One of EstroG-100’s human medical research tracked sufferers with 12 signs of menopause and located EstroG-100 considerably improved in 10 of the 12 main signs over a four-month interval.10

Soyselect® is a patented soy extract from Indena S.p.A particularly developed for the administration of menopause-related signs. It options two standardized isoflavones, which bind to estrogen receptors and saponins that enhance isoflavone bioavailability. Two medical research have related Soyselect with offering aid from scorching flashes and night time sweats11,12, and a 3rd trial confirmed the ingredient’s means to counteract the delicate cognitive decline noticed throughout menopause.13

Turmeric isn’t only a flavorful cooking spice, it’s presently one of many hottest components within the complement market. Indena S.p.A.’s Meriva® is comprised of turmeric’s lively ingredient, curcumin, and has already demonstrated the potential to advertise wholesome ageing in women due to its capability to assist protect muscle mass.14

Data from a forthcoming osteoporosis medical trial on the ingredient can also be proving to be promising. “Curcumin modulates important molecular targets which participate in the regulation of bone remodeling,”15 stated Indena’s Cosimo Palumbo, gross sales space supervisor of North America.

Researchers administered 1 g/d of Meriva to asymptomatic wholesome topics for six months. The research topics had early osteopenia with elevated danger of future osteoporosis. Researchers discovered the every day dose of Meriva resulted within the progressive enchancment of bone density.

Healthy bones depend on the balanced processes of bone formation (by osteoblasts) and bone reabsorption (by osteoclasts). In post-menopausal women, the decline of estrogen may cause extreme bone resorption by osteoclasts with out sufficient bone formation by osteoblasts, leading to osteoporosis.

Another ingredient focused for bone help is ParActin®, by HP Ingredients. A patented Andrographis paniculata extract, the ingredient is standardized to andrographolide, 14 deoxyadngrographolide, and neo-andrographolide and addresses the irritation connection to bone health.

“Andrographolide found in ParActin, a natural NF-kB inhibitor, significantly decreases osteoclast formation in the bone marrow via suppression of RANKL (receptor activator of nuclear factor kappa-B ligand) that are responsible for making osteoclasts,” defined HP’s Annie Eng, CEO. “In an in vitro study, andrographolide found in ParActin inhibited nuclear factors of activated T-cells (NFAT) activity, which regulates the expression of osteoclast genes and is linked to bone erosion.”16

Sexual want waxes and wanes, particularly for women in menopause. Libfem®, a standardized fenugreek extract from GE Nutrients, is focused to assist help wholesome feminine sexual want, promote wholesome sexual arousal in women, and assist scale back regular signs of menopause (similar to scorching flashes and night time sweats).

Libifem has been proven to be efficient in two medical research carried out on wholesome women in Australia. The first research demonstrated the ingredient’s effectiveness in supporting feminine sexual want, hormone ranges and metabolism in women aged 20 to 49.17 The second research targeted on women aged 40 to 65 years who have been experiencing regular menopausal signs, and located Libifem was efficient in decreasing these signs.18

“Women of all ages, are taking charge of their own health, and that of their families,” stated James Hyde, vice chairman and common supervisor, Balchem Human Nutrition and Pharma, and chair, Council for Responsible Nutrition (CRN) board of administrators. “They want to feel good about the choices they make, and to ensure they are getting the most usable and beneficial forms of nutrients and supplements for their money.”

Joanna Cosgrove is a Pennsylvania-based freelance author who has loved overlaying the dynamic dietary complement and wholesome meals and beverage industries for almost 20 years.

References

  1. Grether-Beck S., et al. “Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study.” Br J Dermatol. 2016 Sep 23.
  2. Manisha Juthani-Mehta, et al., “Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial.” JAMA. 2016;316(18):1879-1887.
  3. Marion E. T. McMurdo, et al. “Cranberry or trimethoprim for the prevention of recurrent urinary tract infections? A randomized controlled trial in older women.” J Antimicrob Chemother (2009) 63 (2): 389-395.
  4. Valenzuela, R., et al. “Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil During Gestation and Nursing.” Nutrients 2015, 7, 6405-6424.
  5. Roberfroid MB. “Introducing inulin-type fructans.” Br J Nutr. 2005 Apr; 93 Suppl 1:S13-25.
  6. Pais P, et al. “Impact of a Proprietary Standardized Olive Fruit Extract (SOFE) on Cardio-Ankle Vascular Index, Visual Analog Scale and C-Reactive Protein Assessments in Subjects with Arterial Stiffness Risk.” Drugs R D. 2016 Dec;16(four):355-368.
  7. Knapen MH, et al. “Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.” Thromb Haemost. 2015 May;113(5):1135-44.
  8. Knapen MH, et al. “Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.” Osteoporos Int. 2013 Sep;24(9):2499-507.
  9. Rachoń D et al. “Knowledge and use of hormone replacement therapy among Polish women: estimates from a nationally representative study–HORTPOL 2002.” Maturitas. 2004 Jan 20;47(1):31-7.
  10. Chang, A., Kwak, B.-Y., Yi, Okay. and Kim, J. S. (2012), “The Effect of Herbal Extract (EstroG-100) on Pre-, Peri- and Post-Menopausal Women: A Randomized Double-blind, Placebo-controlled Study.” Phytother. Res., 26: 510–516.
  11. Scambia G., et al. “Clinical effects of a standardized soy extract in postmenopausal women: a pilot study.” Menopause Mar-Apr;7(2):105-11 (2000).
  12. Upmalis D.H., et al. “Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study.” Menopause Jul-Aug;7(four):236-42 (2000).
  13. Kritz-Silverstein D., et al. “Isoflavones and cognitive function in older women: the Soy and Postmenopausal Health In Aging (SOPHIA) Study.” Menopause May-Jun;10(Three):196-202 (2003).
  14. Franceschi Fs.,“A Novel Phospholipid Delivery System of Curcumin (Meriva®) Preserves Muscular Mass in Healthy Aging Subjects.” Eur Rev Med Pharmacol Sci 20 (four), 762-766. 2016.
  15. Rohanizadeh R., BoneKey Reports 2016; 5: 793-799.
  16. Carretta et al. European Journal of Pharmacology. 602(2-Three):413-21, 2009.
  17. Rao, A., et al. “Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study.” Phytother. Res., 2015;29: 1123–1130.
  18. Steels, et al. “Prospective Double Blinded, Randomised, Placebo-Controlled Study to Evaluate Safety and Efficacy of LIBIFEM®, a specialized Trigonella foenum-graecum seed extract, in Reducing Menopausal Symptoms in Otherwise Healthy Women.”


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