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Sex-specific cardiovascular drug dosages needed to reduce adverse reactions in women

Sex-specific cardiovascular drug dosages are needed to reduce adverse reactions in women, in accordance to a place paper from the European Society of Cardiology revealed in European Heart Journal – Cardiovascular Pharmacotherapy.

“Cardiovascular illnesses kill a larger proportion of women than males in Europe, they usually kill twice as many women as all cancers mixed,” stated lead writer Dr Juan Tamargo, director of the Cardiovascular Pharmacology Research Group, Universidad Complutense, Madrid, Spain.

“Cardiovascular drug recommendations are based on clinical trials in middle-aged men,” continued Dr Tamargo. “Women have more adverse reactions from current dosages and may stop taking preventive medication, leaving them unprotected despite their higher risk.”

The place paper outlines the variations between women and males with respect to cardiovascular drugs and provides suggestions on how to enhance remedy in women.

Key variations between women and males with respect to cardiovascular illnesses and medicines:

  • Women are at higher danger of cardiovascular illness than males as a result of they stay longer.

  • Cardiovascular drug suggestions are based mostly on medical trials in middle-aged males.

  • Adverse drug reactions are extra extreme and extra widespread in women than males.

  • Women much less typically obtain preventive remedies and are handled much less aggressively than males.

  • Women and males take up, distribute, metabolise, and excrete medicine in a different way.

Dr Tamargo stated: “Male physicians less often prescribe recommended medications for female patients. Some doctors think cardiovascular disease is not a real issue for women because they are protected by sex hormones, forgetting that this disappears with age and women live longer than men.”

Women have a 1.5 to 1.7-fold higher incidence of adverse reactions to cardiovascular medicine they usually have a tendency to be extra extreme than in males, extra typically needing hospital admission. For instance, women have a better danger of drug-induced torsades de pointes (an irregular coronary heart rhythm than can lead to sudden cardiac demise) and extreme bleeding. Statin-induced myopathy is extra widespread in older women with low physique weight.

“Women have more adverse reactions because for many drugs the same dose is recommended for everyone irrespective of body weight,” stated Dr Tamargo. “This can lead to higher plasma levels and overdoses in women.”

There are sex-related variations in the pharmacokinetics (the best way a drug is absorbed, distributed, biotransformed and excreted) of some extensively used cardiovascular medicine. For instance, the bioavailability and plasma ranges of aspirin are larger in women than males, probably due to decrease exercise of the enzyme aspirin esterase, and higher distribution and decrease clearance of aspirin. These variations vanish with oral contraceptives and through being pregnant.

Dr Tamargo stated: “Sex-related recommendations for drug dosages are not included on labels, even for drugs with a greater than 40% difference in pharmacokinetics between men and women.”

Sex-related variations additionally happen in cardiovascular drug pharmacodynamics (the connection between drug impact and drug focus on the website of motion). For instance, aspirin has a better protecting impact towards stroke in women and towards coronary heart assault in males. Aspirin is extra lively in male platelets, and aspirin resistance is extra frequent in women.

The paper recommends:

  • Develop and implement sex-specific tips for cardiovascular medicine.

  • Include sex-specific dosages on cardiovascular drug labels.

  • Enrol women in medical trials of cardiovascular medicine.

  • Educate docs about intercourse variations in the pharmacokinetics and pharmacodynamics of cardiovascular medicine.

Dr Tamargo concluded: “The most effective way to minimise adverse drug reactions in women is to develop and implement sex-specific guidelines for cardiovascular drugs.”


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